标签：#ics

Transferring genes across species doesn't just happen in microbes.

This article presents a straightforward approach to automatically and efficiently tune hyperparameters for machine learning models using Optuna as the optimisation framework. We explore how to use both Optuna’s native storage options and InterSystems IRIS as a database backend to track the progress of hyperparameter searches. We also show how MLflow can be used to monitor experiments and manage models through its tracking and model registry UI. This article is based on this Kaggle Notebook , which you can run and directly edit yourself. When training ML models, the choice of hyperparameters can strongly influence performance. They are not the only factor, but they can significantly affect both convergence and generalisation. Tuning hyperparameters manually takes a lot of effort. This is especially true because hyperparameters interact with each other, so tuning them independently is usually not enough. For example, higher regularisation may require a lower learning rate for more stable optimization. A more complex model may require stronger regularization to avoid overfitting, but at the same time, a very small learning rate on a complex model can make learning too slow. Optuna is an MIT-licensed open source library, which allows commercial use, that automates hyperparameter search for ML models developed with the most popular frameworks such as scikit-learn, PyTorch, TensorFlow, and LightGBM. It works by defining a search space and an objective metric to either minimize or maximize. Optuna then explores the search space efficiently to find well-performing configurations. Here we use Optuna to tune a LightGBM model on a dummy dataset and show how to scale the search using shared database storage. We will also use MLflow for experiment tracking and model registry, and IRIS DB as a possible Optuna storage backend for concurrent studies. We will use the California Housing dataset, commonly used in ML examples, to populate IRIS tables and run the tuning workflow. Note:

There's a line usually pinned on the Roman philosopher Seneca: luck is what happens when preparation meets opportunity. People put it all over social media and like most things on social media, it gets repeated so often that it stops meaning anything. So let me try to make it mean something again, with a math equation and a football match that happened recently at the latest FIFA World Cup 2026. The equation nobody writes down We talk about luck like it's a single mysterious force, either you have it or you don't. But it's not one thing. It's two things multiplied together: Luck = Preparation × Opportunities Look at what that multiplication does. If your preparation is zero, it doesn't matter how many opportunities show up, zero times anything is still zero. And if you're the most prepared person alive but you never put yourself in front of a single opportunity, same result. Zero. The lucky people aren't the ones who got more luck handed to them. They're the ones who kept both numbers high. They got good and they kept showing up to the table where things happen. Hold that thought. Let's go to Texas. Japan, the Netherlands, and the 88th minute On June 14th, 2026, Japan played the Netherlands in their World Cup group opener in Arlington, Texas. On paper it was a mismatch in the most literal, physical sense. The Netherlands are tall . Van Dijk, Van de Ven, the whole spine of that team is built like a row of wardrobes. Japan are one of the shorter sides in world football, quick, technical, but not the people you'd bet on to win a header. If you were designing a contest specifically to humiliate the Japanese, you'd make it about jumping. And for most of the night, the script ran exactly as the bodies predicted. The Dutch dominated the run of play, around 60% possession, more passes, more touches in the box, the better expected goals. Van Dijk, a defender, rose for a cross and headed the Netherlands ahead. Later Summerville restored their lead. The Oranje even won the aer

In a bid to dismiss a lawsuit over xAI’s polluting gas turbines, the Justice Department claimed the company is integral to military operations—including the Iran War.

You scan one to pay at a sari-sari store, pull up a restaurant menu, or board a flight. The QR code has quietly become one of the most universal pieces of interface design on the planet. But it was never meant for any of that. The QR code was invented in 1994 to solve a very specific problem on a Japanese car factory floor, and the engineering decisions made under that constraint are exactly why it later conquered the world. A barcode problem on the assembly line In the early 1990s, Toyota's manufacturing arm had a data problem. Tracking thousands of distinct components through production meant scanning barcodes, and barcodes are stingy: a standard one-dimensional barcode holds roughly 20 characters. Workers were ending up with parts plastered in ten or more barcodes just to encode enough information, and each one had to be scanned separately. It was slow, and on an assembly line, slow is expensive. Masahiro Hara, an engineer at Denso Wave, a Toyota subsidiary, took on the challenge of designing something better. He wanted a code that could hold far more data, be read much faster, and tolerate the dirt, smudges, and odd angles of a real factory rather than a clean lab. Designing for speed and any angle The breakthrough was going two-dimensional. By encoding data in a grid of black and white squares rather than a single row of lines, Hara's team could pack in thousands of characters instead of a few dozen. The name they chose, QR for "Quick Response," was a direct promise about scanning speed. The most recognizable feature of a QR code, the three large squares in its corners, solves the hardest part of the problem: letting a scanner instantly find the code and work out its orientation no matter how the part is turned. Hara's team analyzed printed material to find a black-and-white sequence that almost never occurs naturally in text and images, and settled on a ratio of 1:1:3:1:1 for those corner markers. Because that pattern is so rare in everyday print, a scanner ca

Anthropic was already navigating one dispute with the government in its standoff with the Pentagon, and then came an order on June 12th to block off foreign access to its most recently released AI models, Fable 5 and Mythos 5. When they launched on June 9th, Anthropic said “Fable 5’s capabilities exceed those of any […]

For months, Big Tech's Washington lobbyists have chased after the holy grail of pro-AI legislation: preemption. This would be a comprehensive federal law, passed in Congress and signed by the president, applying one set of AI rules across the entire country and overriding the legally messy state-by-state approach to regulation. For months, lobbyists have run […]

From the day it was announced, on June 16th, 2025, the Trump phone sounded ridiculous. The T1 Phone 8002 (gold version), as it was officially called, was a combination of contradictory specs, product images that were clearly not photographs of a real phone, and the worrying requirement of a $100 deposit to secure a preorder […]

Both kratom and one of its active components, 7-OH, have opioid-like effects and are widely available across the US. As health secretary RFK Jr. aims to get 7-OH banned, proponents of both are fighting.

The federal government is planning to let a rule regulating federal data center operations sunset in September with no replacement.

The UK is the latest country to follow Australia in implementing a total social media ban for children under 16, Prime Minister Keir Starmer has announced. The ban, which could take effect from early next year, will be joined by wider measures that will also prevent children from talking to strangers in online games, livestreaming, […]

Three days into November, a disapproval cascade pulled 40% of active SKUs from Shopping and Performance Max simultaneously — on day one of a promotional window we'd spent six weeks building. No feed changes on our side triggered it. Here's the part most guides miss: Google's automated review threshold for certain policy categories (health claims, price accuracy, before/after imagery) tightens as platform ad volume increases heading into Q4. I've watched this happen across accounts running ₩50M–₩120M/month in combined Google spend, three years in a row, with zero feed-side changes preceding it. Same feed that sailed through August catches 15–20% disapprovals on recheck in September. The products didn't change. The enforcement did. When it hits during a live window, fix order matters more than fix speed. Price mismatches go first — not because they're the most dramatic, but because they cascade silently. One bestseller disapproved during a flash sale means Performance Max quietly reallocates budget to lower-performing products. By the time ROAS visibly drops, you've lost 48 hours of peak traffic. The specific failure mode I've seen twice on Cafe24 with direct API feeds: a site-wide price update propagates to the feed before the landing page CDN cache clears. Google crawls the feed, sees the new price, crawls the landing page, sees the old cached price. Mismatch. Disapproval. Fixing it is one line — force a manual fetch and verify sale_price_effective_date formatting — but finding it at 2am during a live sale is a different problem. Prohibited content disapprovals are deprioritized by most teams because they're rare. That's exactly wrong. A single escalation during Black Friday week can trigger account-level review, not just product suspension. Pull the SKU yourself within the hour if you can't fix the content immediately. Suspending your own SKU is recoverable. A suspended account during peak is not. GTIN and identifier issues — despite getting the most attention in s

Plug a sensor into a switch, wire up a building full of cameras, or rack a server, and you are using Ethernet. It is the most widely deployed wired networking standard on earth, the quiet backbone under offices, factories, and data centers. And it is named after a scientific idea that turned out to be completely wrong. The name was not an accident or a marketing afterthought. It was a deliberate engineering choice, and the reasoning behind it explains why Ethernet outlived nearly every rival and still underpins industrial IoT half a century later. A memo, a laser printer, and a dead theory The date Ethernet enthusiasts celebrate is May 22, 1973. On that day, a young engineer named Robert Metcalfe, working at Xerox's legendary Palo Alto Research Center (PARC), circulated a memo describing how to connect the Alto - one of the first personal computers - to a new device PARC had built: the laser printer. The problem was getting many machines to share one wire without their messages colliding into noise. Metcalfe needed a name for the shared medium that carried the signals. He reached back into nineteenth-century physics and borrowed the term luminiferous ether . For generations, physicists had assumed that light, being a wave, needed something to wave through - just as sound needs air. They called that invisible, all-pervading substance the ether, and they believed it filled the entire universe as a silent carrier of electromagnetic waves. The trouble is that the ether does not exist. The famous Michelson-Morley experiment of 1887 failed to detect it, and Einstein's special relativity in 1905 made it unnecessary altogether. By the time Metcalfe wrote his memo, the luminiferous ether had been a discredited idea for decades. He used it anyway, and on purpose. Why a debunked idea made for brilliant engineering Metcalfe later explained the choice plainly: "We called it Ethernet because the ether could be coax, twisted pair, radio, optical fibers, power line, whatever you wa

According to a new report from Semafor, the White House's decision to impose export restrictions on Anthropic's Mythos was driven in part by fears that it had been accessed by a group linked to China. If the Chinese government actually had access to Mythos 5 or Fable 5, it would present a serious national security […]

Traditional databases just can't keep up with high concurrency and low latency at the same time. The term "real-time" has become kind of meaningless. Everyone claims it, from batch-oriented cloud data warehouses to transactional database extensions. This makes picking the right architecture really hard without expensive trial and error. The best real-time analytics database in 2026 depends entirely on your workload shape. Key takeaways Real-time analytics (in this guide) = sub-second p95/p99 analytical queries on billions of rows, high concurrency , and milliseconds-to-seconds freshness . Best overall in 2026 for most workloads: ClickHouse (ingest throughput, query speed at scale, compression/TCO). Best for strictly predefined query paths via star-tree indexes: Apache Pinot . Best for time-series operational dashboards and observability: ClickHouse . ClickStack is its full observability offering for logs, metrics, and traces. Best for rigid ingestion-time roll-up aggregations: Apache Druid . Best for unified OLTP + real-time analytics: ClickHouse paired with its managed Postgres offering and native sync to ClickHouse , giving you a purpose-built OLTP engine and a purpose-built OLAP engine without rolling your own CDC pipeline. SingleStore is an alternative if you prefer a single HTAP engine for both. Traditional Data Warehouses: Snowflake and BigQuery are fine for batch BI if you already have one, but face latency, concurrency, and cost challenges under sub-second, high-concurrency workloads. Evaluate using 4 axes: ingest/freshness, latency under concurrency, TCO, operational complexity. What 'real-time analytics' means (and why warehouses and OLTP databases fail) Strict engineering thresholds define true real-time OLAP : sub-second query latency on complex aggregations, the ability to serve tens to thousands of concurrent queries per second (QPS), and data freshness measured in milliseconds to seconds. Traditional cloud data warehouses like Snowflake and BigQuery a

Token economics is not only about token price. It is about designing the rules, incentives, and long-term logic of a Web3 ecosystem. When people start building a Web3 project, they usually focus on the visible parts first. They think about the smart contract, the frontend, the wallet connection, the token launch, the whitepaper, and maybe the community. All of those are important. But there is one part that can decide whether the project survives or fails: Token economics. A project can have clean smart contracts, a nice UI, and strong marketing, but if the token economy is weak, the project can slowly collapse. Users may come only for rewards, early investors may dump, inflation may destroy value, and the token may lose its reason to exist. That is why token economics should not be treated as just a “crypto finance” topic. For developers and Web3 builders, token economics is closer to system design . It defines how value moves inside the ecosystem, how users are rewarded, how supply is controlled, how governance works, and how the project can grow without depending only on hype. What Is Token Economics? Token economics, often called tokenomics , means the design of how a token works inside a project. It answers questions like: Why does this token exist? Who receives the token? How is the token used? How many tokens will exist? How are rewards distributed? When can team and investor tokens unlock? How does the project treasury work? What creates real demand for the token? In simple words, token economics is the rule system behind a token. A token is not only something people buy and sell. In a real Web3 product, a token can be used for payments, staking, governance, access, rewards, collateral, or network fees. If the token has no clear role, it becomes only a speculative asset. That is dangerous because speculation can bring attention, but it cannot support a project forever. Why Developers Should Care Some developers think token economics is only for founders, eco

On Friday evening, the government ordered Anthropic to block access to Fable 5 and Mythos 5 for all foreign nations, both inside and outside the US, due to national security concerns. That order included employees of Anthropic. To meet those demands, the company has completely cut off access to the models for all customers. In […]

As World Cup action kicks off, we look at the physics of the beautiful game.

Observability isn't just a buzzword; it's a necessity, especially when diving into distributed systems. If you're using NestJS, you might want to take a look at RedisX. It's a modular toolkit that can boost the observability of your applications. A standout feature? The Metrics Plugin. It meshes well with Prometheus, delivering insights into Redis operations in your NestJS setup. Getting RedisX Metrics Rolling in NestJS So, first things first. To harness the power of RedisX Metrics, you need to set up your NestJS app with RedisX. This means installing some packages and configuring the RedisModule with the MetricsPlugin. Hit your terminal and run: npm install @nestjs-redisx/core @nestjs-redisx/metrics Now, let's tweak your AppModule . You want it to use RedisModule with MetricsPlugin: import { Module } from ' @nestjs/common ' ; import { ConfigModule , ConfigService } from ' @nestjs/config ' ; import { RedisModule } from ' @nestjs-redisx/core ' ; import { MetricsPlugin } from ' @nestjs-redisx/metrics ' ; @ Module ({ imports : [ ConfigModule . forRoot ({ isGlobal : true }), RedisModule . forRootAsync ({ imports : [ ConfigModule ], inject : [ ConfigService ], plugins : [ new MetricsPlugin ({ prefix : ' redisx_ ' , endpoint : ' /metrics ' , defaultLabels : { service : ' my-service ' } }) ], useFactory : ( config : ConfigService ) => ({ clients : { host : config . get ( ' REDIS_HOST ' , ' localhost ' ), port : config . get ( ' REDIS_PORT ' , 6379 ), }, }), }), ], }) export class AppModule {} Prometheus Metrics: What You Get With MetricsPlugin set up, your app now exposes a /metrics endpoint. Prometheus can scrape this endpoint, dishing out detailed metrics about your Redis operations. Here's a snapshot of what you get: redisx_cache_hits_total : Tracks total cache hits. redisx_lock_acquired_total : Total locks acquired. redisx_redis_commands_total : Total Redis commands run. Making Prometheus Work for You To get those insights, set up Prometheus to scrape your /metrics end

AI 工具整合評估報告 執行摘要 本報告評估了 7 個 AI 工具在臨床基因體學領域的應用潛力，重點測試了 3 個優先級最高的工具：MedGemma 醫療大語言模型、Nemotron RAG 文獻檢索系統，以及 Kimi K2.5 多模態視覺語言模型。 評估日期 : 2026-02-10 測試平台 : RTX 3090 24GB 評估目標 : 確認 AI 工具在變異解釋與臨床決策中的可行性 1. 測試項目總覽 1.1 優先級分類 P1 (高優先級) - 已評估: ✅ MedGemma - Google DeepMind 醫療大語言模型 ✅ Nemotron RAG - NVIDIA 文獻檢索與知識整合 ✅ Kimi K2.5 - 月之暗面多模態視覺語言模型 P2 (中優先級) - 已規劃: 📋 Gemini CLI Hooks - 工作流自動化 📋 DaGGR - Hugging Face 基因體學工具 📋 評測方法論 - 醫療 AI 評估框架 P3 (低優先級) - 待調研: 📋 OpenEvidence - 臨床證據檢索引擎 2. MedGemma 醫療大語言模型 2.1 工具概述 開發者 : Google DeepMind 基礎模型 : Gemma 7B 特化領域 : 醫療問答、臨床決策支持 技術規格 : { "model_size" : "7B parameters" , "quantization" : "8-bit (optional)" , "gpu_requirement" : "12-16GB VRAM" , "context_length" : "8192 tokens" , "languages" : "English (primary)" } 2.2 功能評估 核心能力 : 醫療知識問答 疾病症狀解釋 藥物機制說明 治療方案建議 基因變異解釋 基因功能說明 變異影響評估 臨床意義解讀 文獻摘要生成 PubMed 摘要 臨床指南解讀 研究結果總結 2.3 應用場景 場景 A: 變異臨床意義解讀 # 輸入 query = """ 變異資訊: - 基因: BRCA1 - 位置: chr17:41234470 - 變化: c.5266dupC (p.Gln1756Profs*74) - 類型: Frameshift 請解釋此變異的臨床意義。 """ # MedGemma 輸出 (預期) """ BRCA1 c.5266dupC 變異分析: 1. 變異類型: Frameshift insertion - 導致讀框位移 - 產生提前終止密碼子 (位置 1756+74) 2. 基因功能影響: - BRCA1 是腫瘤抑制基因 - 參與 DNA 雙鏈斷裂修復 - Frameshift 導致功能喪失 3. 臨床意義: - 致病性: Pathogenic (高可信度) - 疾病風險: 遺傳性乳腺癌/卵巢癌 (HBOC) - 乳癌風險: 55-72% (終生風險) - 卵巢癌風險: 39-44% 4. 臨床建議: - 遺傳諮詢 - 加強監測 (MRI + 超音波) - 考慮預防性手術 - PARP 抑制劑治療 (若已診斷) """ 場景 B: 醫療文獻查詢 query = " What are the latest treatments for TP53-mutated cancers? " # MedGemma 回答 (模擬) """ TP53 突變癌症的最新治療策略: 1. 標靶治療: - APR-246/Eprenetapopt: 恢復 TP53 功能 - PRIMA-1/APR-246: 臨床試驗進行中 2. 免疫治療: - PD-1/PD-L1 抑制劑 - TP53 突變可能影響免疫反應 3. 合成致死策略: - PARP 抑制劑 (部分 TP53 突變) - ATR/CHK1 抑制劑 4. 臨床試驗: - NCT02999893: APR-246 + 化療 - NCT03745716: TP53 疫苗免疫治療 """ 2.4 部署考量 技術需求 : GPU記憶體: 12-16GB (FP16) 或 8GB (INT8) 推理延遲: 2-5 秒/查詢 API 或本地部署均可 整合方案 : # 與變異註釋流程整合 def annotate_with_medgemma ( variant ): # 1. 提取變異資訊 gene = variant [ ' gene ' ] change = variant [ ' protein_change ' ] # 2. 生成查詢 prompt = f " Explain the clinical significance of { gene } { change } " # 3.