This week, researchers at the University of Minnesota announced something that genuinely stopped me mid-scroll. A team led by Associate Professors Kate Adamala and Aaron Engelhart built the world's first synthetic cell with a complete life cycle — not modified from an existing organism, not borrowed from biology. Built. From. Scratch. They're calling it SpudCell . It can grow. It feeds. It copies its own genetic material. It divides into new cells. And it does all of this from a starting point of pure chemistry — non-living components assembled with intent. Adamala put it plainly: "We've replicated in chemistry what only used to be possible in biology: the complete set of behaviors of a cell. It proves that the most fundamental functions of life, like growth and replication, do not need a mysterious magical spark." — University of Minnesota That's not hype. That's a scientist who has spent her career working toward this moment, choosing her words carefully. What SpudCell Actually Is SpudCell isn't a copy of a bacterium or a stripped-down version of an existing cell. It's a chemically defined system — meaning researchers know the full ingredient list, every molecule at every concentration. To put the scale in perspective: the human genome runs about 3 billion base pairs. SpudCell's genome is 90 kilobase pairs. Minimal by design. But minimal doesn't mean simple — it means precise . Every component earns its place. — CBS Minnesota The cell mostly resembles a basic bacterium in its behavior, but it carries none of evolution's baggage. No millions of years of accumulated quirks. No legacy code. Just the essential machinery for life's core functions, assembled on purpose. Yuval Elani, a synthetic biology researcher at Imperial College London, framed it this way: "Building a cell from scratch means you are no longer tied to the constraints and evolutionary baggage of natural biology. It opens up the possibility of designing systems and programming them to do things that li

Hi everyone, I built H64LM, a research project to better understand modern LLMs by implementing one from scratch in PyTorch. Instead of relying on high-level training frameworks, I implemented the core components myself attention, MoE routing, normalization, and the training loop. Features 249M-parameter Transformer Grouped Query Attention (GQA) Sparse Mixture-of-Experts (8 experts, Top-2 routing) with 3 auxiliary routing losses SwiGLU, RoPE, RMSNorm Sliding-window attention Mixed-precision training, gradient accumulation Custom training loop (no Trainer abstractions) Checkpointing and resume support The included checkpoint was trained on a subset of WikiText-103 to validate the pipeline end-to-end, not to be a strong model it's visibly overfit past epoch 10 (best val PPL ~40.5). Known limitations are documented in the README, including batch-size-1-only generation and no true DDP (falls back to DataParallel). GitHub: https://github.com/Haiderkhan64/H64LM Feedback on the implementation or architecture is very welcome. submitted by /u/Loose_Literature6090 [link] [留言]

There's a phase almost every developer gets stuck in. You're consuming tutorials, bookmarking articles, finishing courses, and buying books you'll read "eventually." You're learning constantly — but you're not producing anything. You're just... absorbing. That's the learning vacuum. And if you've been there, you know how easy it is to confuse staying busy with making progress. At some point, the shift has to happen. You stop being a sponge and start being a signal. Here's how I started making that turn. Start a Daily or Weekly Code Journal You don't need a blog, a brand, or an audience for this. Just a file. A note. Anything. Write down what you built, what broke, and what you figured out. Even one sentence counts. I like to write a quick sentence and how many hours, just like if you were filling in an invoice for contract work. The act of putting it into words forces you to actually process what you learned instead of letting it blur into the background noise of your brain. Over time, those entries start to look like a roadmap — and you realize you've come further than you thought. Code Something You Actually Want to Build Pick something dumb. Pick something fun. A browser game, a weird UI experiment, a tool that solves exactly one tiny problem in your life. I signed up for DEV Challenges , Summer Bug Challenge and upcoming Weekend Challenge to get my ball rolling. The best projects I've ever worked on had no real-world utility. They were just interesting to me. And that interest kept me showing up even when things got hard. A tutorial can't give you that. Only a project you actually care about can. Find Your People Whether it's here or a Discord server, a local meetup, a dev community on Farcaster or Lens, or just a forum thread you keep coming back to — find somewhere to show up regularly. Lurking is fine at first. But eventually, drop a comment. Answer a question you know the answer to. Share something you built. Community is where isolated learning becomes shar

Every business that has ever typed a web address into a browser owes a small debt to a company most people have never heard of. On March 15, 1985, a computer maker called Symbolics registered Symbolics.com and, in doing so, became the first ever holder of a .com domain name. More than forty years later that address is still registered and still resolves - making it the oldest .com domain on the internet. Who was Symbolics? Symbolics Inc. was a Massachusetts company that built specialized computers called Lisp machines - workstations designed from the silicon up to run the Lisp programming language, then the darling of artificial intelligence research. These were serious, expensive machines aimed at labs and universities, and the company sat right at the cutting edge of 1980s computing. So it was fitting, if a little accidental, that they were first in line when commercial domains became available. The domain name system itself was brand new. DNS had only been introduced in 1983 to replace the unwieldy HOSTS.TXT file that every machine on the early internet had to keep in sync. The now-familiar top-level domains - .com , .org , .net , .edu , .gov - were defined in 1984. When registration opened, .com was meant for commercial entities, and Symbolics grabbed theirs before anyone else did. A slow start for the web's most valuable real estate What is striking today is how little demand there was. In the whole of 1985, only a handful of .com domains were registered - names like BBN, Think, and a few other technology companies trickled in over the following months. There was no gold rush, because there was no web yet. Tim Berners-Lee would not propose the World Wide Web until 1989, and the first website would not appear until 1991. A domain name in 1985 was a technical convenience for reaching a machine, not a brand or a piece of property. That makes Symbolics.com a kind of time capsule. It was registered before the web, before browsers, before e-commerce, and before anyon

Watch your AI coding agents build, live in 3D Discussion | Link

A 62-year-old man in India. Kidney failure, on dialysis three times a week. Diabetes. Hypertension. A stroke six years ago. And one symptom nobody could explain: severe headaches, but only when lying down to sleep. For 25 years, specialists came up empty. Then his nephew uploaded everything into Claude. And the AI asked one question that changed everything: "Does he snore?" The answer was yes. Loudly. For 25 years. That was the clue. The sleep study confirmed severe sleep apnea: 119 breathing stops per night, oxygen dropping to 78%, 47 oxygen desaturations per hour. CPAP treatment started. Headaches gone. ( India Today , NDTV ) What Actually Happened The story was posted on Reddit's r/ClaudeAI community by user u/the_kuka in March 2026. It went viral immediately, covered by India Today, NDTV, Hindustan Times, Economic Times, and Times of India within days. Here's the timeline: 25 years of symptoms. The uncle had loud snoring, daytime exhaustion, and severe positional headaches (only when lying down). Every doctor attributed the fatigue to "dialysis fatigue" or "age." The snoring was something the family joked about. Multiple specialists, zero connections. He saw neurologists. He saw nephrologists. He had brain MRIs and blood work. Each specialist looked at their domain. Nobody stepped back and asked what connected everything. One conversation with Claude. The nephew compiled all medical records, MRI notes, and symptom history, and uploaded them. Over several days, Claude did three things: Identified the positional pattern as the key clue. Headaches triggered by lying down is not random. It points to something that happens during sleep. Pulled research showing 40-57% of dialysis patients have undiagnosed sleep apnea. This is a published statistic, not a guess. Asked about snoring. This is the question no specialist had asked in 25 years. The answer was immediate and obvious in hindsight. ( Substack - Chetan Pujari ) The sleep study confirmed it. Severe obstructive sl

Article URL: https://www.ycombinator.com/companies/infracost/jobs/YTJcFwr-marketing-lead Comments URL: https://news.ycombinator.com/item?id=48779906 Points: 0 # Comments: 0

AI Checklist Maker - Beautiful PDFs, Free & Instant Discussion | Link